Registration Dossier

Administrative data

Description of key information

No measured data are available for 2-methyl-1-heptanol, so the endpoint requirements are fulfilled by read-across from a structural analogue, the linear isomer octan-1-ol. 
The key study for skin irritation (Johnson 1996; rel 1) in rabbit reports 1-octanol to be mildly irritating to skin, but not to exceed the values which would lead to EU classification. Conversely the key study for eye irritation (Johnson 1996; rel 1) found 1-octanol to be an eye irritant based on the persistence of iritis and conjunctivitis to 22 days.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

The key studies were chosen for the irritation endpoints as they were the most reliable and recent studies available. The skin irritation supporting studies were in accordance with the key findings, with a report of a human study which did not find 1-octanol irritating to skin when tested in 25 volunteers, following a 48 closed application (Opdyke 1973).

The key eye irritation study which was conducted with only 3 animals found 1-octanol category 1 irritant to the eye. A reliability 1 supporting study (ECETOC 1998) reported scores of =>2 for corneal opacity, =>1 for iritis and =>2 for chemosis, with the lesions reversible within 14 days and the test substance therefore classifiable as a category 2 irritant. The second supporting study (Jacobs, 1987; rel 2) also found the test substance irritating, however with the observation period only extending to 96 hours post instillation. The results suggest that despite the expected variability in response, particularly in cases in which lower number of animals was used, there is direct evidence that the effects of 1 -octanol can be regarded as reversible.

In addition, based on the available data on 1 -hexanol and 1 -decanol weight of evidence suggests that 2-methyl-1-heptanol should be classified as a category 2 eye irritant.


Effects on eye irritation: irritating

Justification for classification or non-classification

Based on the available information for the read-across substance, 1-octanol, the registration substance 2-methyl-1-heptanol is proposed to be a category 2 eye irritant according to EU criteria. The test substance was not found irritating to skin according to current guideline and does not require classification, in accordance with CLP (EC regulation 1272/2008).