Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 809-896-5 | CAS number: 60435-70-3
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
For the linear analogue octan-1-ol, two bacterial mutagenicity studies are available, in one of which only two strains were tested. The key study for this endpoint is therefore the older study. Both results were negative. For endpoints where there is no information on octan-1-ol, key studies were chosen from studies on closely related linear or branched alcohols of similar chain length. The choice of key study was based on reliability and similarity of chain length. The data available from standard in vitro and in vivo genetic toxicity assays for all related substances show no evidence of mutagenic potential.
Short description of key information:
Measured data are not available for 2-methyl-1-heptanol, therefore measured data for structurally analogous alcohols are read across.
In vitro information:
Gene mutation (Bacterial reverse mutation assay / Ames test): negative with and without activation (similar to OECD TG 471) typhimurium strains TA
Cytogenicity in mammalian cells: information not required because in vivo information for a closely related substance is available
Mutagenicity in mammalian cells: the related substance 2-ethylhexan-1-ol was negative with and without activation in L5178Y mouse lymphoma cells (similar to OECD TG 476)
In vivo
Chromosome aberration study in rats: the related substance 1-dodecanol was negative in mice after oral administration (gavage) (similar to OECD TG 475)
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Octan-1-ol is a member of the category aliphatic alcohols. The category members contain no structural elements which may be of concern for potential mutagenic activity. In vitro tests over the carbon range (C6-22) of the long chain alcohols category members (primary aliphatic alcohols) and supporting substances (C5-C24-34) are negative including two studies for octan-1-ol [Ames]. Evidence from in vivo studies on other category members supports the conclusion that these alcohols are not genotoxic in vivo. Negative data of reliability 1 or 2 in support of this conclusion are available for 2-ethyl hexanol (supporting) [negative chromosome aberration assay] and dodecan-1-ol [negative micronucleus assay].
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
