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EC number: 295-405-4
CAS number: 92045-23-3
A complex combination of hydrocarbons produced by the distillation of the products of a steam cracking process. It consists predominantly of hydrocarbons having a carbon number of C4, predominantly 1-butene and 2-butene, containing also butane and isobutene and boiling in the range of approximately minus 12°C to 5°C (10.4°F to 41°F).
no effect on the body weight of the animals and no indications of
toxicity were observed during the daily observations of the in-life
portion of the study. Statistically significant increases in the
frequencies of MN-PCE in both sexes of all groups treated with the test
material were observed as compared to the negative controls. Although
statistical analyses indicated a significant dose response, the
difference in MN-PCE incidence at the high- (20 mg/L) and low- (0.5
mg/L) dose was minimal. The positive control treatment induced a
significant increase in the frequency of MN-PCE. The mean proportion of
PCE among the erythrocytes (200/animal) in the bone marrow was not
affected following exposure to the test material while the positive
control treatment significantly reduced this value.
Butadiene (Low 1,3-Butadiene Content) was tested in a mouse bone-marrow micronucleus
assay. C3H/HeNCrlBR mice were exposed to 20mg/L (20,000 mg/m3)for 4h/day
for 2 days. A positive result was obtained.
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