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EC number: 295-405-4
CAS number: 92045-23-3
A complex combination of hydrocarbons produced by the distillation of the products of a steam cracking process. It consists predominantly of hydrocarbons having a carbon number of C4, predominantly 1-butene and 2-butene, containing also butane and isobutene and boiling in the range of approximately minus 12°C to 5°C (10.4°F to 41°F).
molecular epidemiology study was conducted at a BD facility in the Czech
Republic in order to evaluate the use of various biomarkers of exposure
and genotoxicity to BD. Eighty-three
male volunteers participated in the study: 24
in BD monomer production, 34 in polymerization activities, and 25 plant
administrative workers served as unexposed control subjects. Prior
to collecting biological samples, there was a 60-day exposure assessment
period, during which BD exposure level measurements were taken for both
the BD-exposed and unexposed control workers. At
the end of the exposure assessment period, blood and urine samples were
study was conducted in a blind fashion. The mean BD exposures were: 0.29
ppm (0.64 mg/m3) for the BD monomer production workers; 0.81
ppm (1.79 mg/m3) for
the polymerization workers; and 0.01 ppm (0.022 mg/m3) for
the controls. There
were no statistically significant differences in the distributions of
metabolic genotypes among the three exposure groups. None
of the specific genotypes showed any heightened susceptibility to BD,
although some specific genotypes were associated with quantitative
differences in urinary metabolite concentrations of hemoglobin adducts. There
was no association between BD exposure and mutations or cytogenetic
effects in the blood of BD-exposed workers. Biomarkers
of exposure (urinary metabolites and hemoglobin adducts), however, were
demonstrated to be valid surrogate measures of BD exposure.
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