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EC number: 295-405-4
CAS number: 92045-23-3
A complex combination of hydrocarbons produced by the distillation of the products of a steam cracking process. It consists predominantly of hydrocarbons having a carbon number of C4, predominantly 1-butene and 2-butene, containing also butane and isobutene and boiling in the range of approximately minus 12°C to 5°C (10.4°F to 41°F).
no deaths or treatment-related clinical observations noted. No
significant differences in parental body weights, body weight gains or
feed consumption were observed at any dose level tested throughout the
duration of the study. The only exception to this was a statistically
identified increase in feed consumption noted for the 10 mg/L satellite
females during the premating period (days 7-14). However, this increase
was considered spurious, as feed consumption increases were not noted
during subsequent gestation and lactation periods and similar changes in
feed consumption were not observed at the highest exposure level of 20
mg/L. There were no treatment-related effects at any dose level on any
of the reproductive parameters evaluated in this study. These included
measures of reproductive performance (mating, conception and fertility,
time to mating, gestation length, litter size), offspring survival
(gestation and postnatal survival indices, percent pre- and
post-implantation loss), pup body weight and pup sex ratio. The only
statistically identified change in any of these parameters was an
increase in post-implantation loss occurring only at the low-dose. This
was considered a spurious finding, given the lack of a dose response. Of
the 12 females mated in each group, the number of viable litters
produced was 11, 11, 11, and 12 for the 0, 2, 10 and 20 mg/L exposure
level groups, respectively. External morphological alterations observed
in the pups were limited to a hernia observed in a single pup from the
high dose group. Given the low incidence of this finding, it was
considered spurious and unrelated to exposure.
and female Sprague Dawley rats were exposed to C4 Crude Butadiene by
inhalation at levels of 0, 2, 10, or 20 mg/L (6h/day, 7 d/week) for two
weeks prior to breeding, during breeding (up to two weeks), and
continuing through day 19 of gestation. After birth pups
were maintained until postnatal day 4. There
were no treatment-related adverse effects on any measures of
reproductive function. Based on these data, the NOAEC for reproductive
toxicity was 20 mg/L (20,000 mg/m3), the highest concentration tested.
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