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EC number: 295-405-4
CAS number: 92045-23-3
A complex combination of hydrocarbons produced by the distillation of the products of a steam cracking process. It consists predominantly of hydrocarbons having a carbon number of C4, predominantly 1-butene and 2-butene, containing also butane and isobutene and boiling in the range of approximately minus 12°C to 5°C (10.4°F to 41°F).
Members of the C4 high 1,3-butadiene category show low sub-chronic toxicity and low potential for neurotoxicity. Inhalation exposure is the most relevant route. No significant exposure-related toxicological or neurotoxicological effects have been observed in inhalation studies of up to 90 days duration on the component substances butane and isobutane.
Repeat dose toxicity data with neurotoxicity
assessments are available for two of the component substances of the C4 high
1,3-butadiene category (butane and isobutane). No systemic toxicity
(i.e., no affect on survival, haematological or clinical chemistry
parameters, food consumption, body weight, organ weight, and
histopathology) or neurological effects (as measured by clinical
observations, functional observational battery, and motor activity) were
observed in 6-week studies to modern guidelines and GLP in which
isobutane, butane and were administered to rats by inhalation. The
NOAECs for both studies were the maximum dose levels tested (9000 ppm,
21,394 mg/m3) (HLS 2008, 2010).
the C4 high 1,3-butadiene category are flammable gases at room
temperature and therefore dermal and oral exposure is unlikely. They
have low sub-chronic inhalation toxicity and studies which included
evaluation of neurotoxicity parameters indicate low potential for
under the DPD or CLP is not warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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