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EC number: 295-405-4
CAS number: 92045-23-3
A complex combination of hydrocarbons produced by the distillation of the products of a steam cracking process. It consists predominantly of hydrocarbons having a carbon number of C4, predominantly 1-butene and 2-butene, containing also butane and isobutene and boiling in the range of approximately minus 12°C to 5°C (10.4°F to 41°F).
Members of the C4 high 1,3-butadiene category show low sub-chronic toxicity and low potential for neurotoxicity. Inhalation exposure is the most relevant route. No significant exposure-related toxicological or neurotoxicological effects have been observed in inhalation studies of up to 90 days duration on the constituent substances butane and isobutane.
Repeat dose toxicity data with neurotoxicity
assessments are available for two of the constituent substances of the
C4 high 1,3-butadiene category (butane and isobutane). No systemic
toxicity (i.e., no affect on survival, haematological or clinical
chemistry parameters, food consumption, body weight, organ weight, and
histopathology) or neurological effects (as measured by clinical
observations, functional observational battery, and motor activity) were
observed in 6-week studies to modern guidelines and GLP in which
isobutane, butane and were administered to rats by inhalation. The
NOAECs for both studies were the maximum dose levels tested (9000 ppm,
21,394 mg/m3) (HLS 2008, 2010).
the C4 high 1,3-butadiene category are flammable gases at room
temperature and therefore dermal and oral exposure is unlikely. They
have low sub-chronic inhalation toxicity and studies which included
evaluation of neurotoxicity parameters indicate low potential for
under CLP is not warranted.
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