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EC number: 295-405-4
CAS number: 92045-23-3
A complex combination of hydrocarbons produced by the distillation of the products of a steam cracking process. It consists predominantly of hydrocarbons having a carbon number of C4, predominantly 1-butene and 2-butene, containing also butane and isobutene and boiling in the range of approximately minus 12°C to 5°C (10.4°F to 41°F).
Members of the C4 high 1,3-butadiene category are flammable gases at room temperature and therefore the requirement for data on skin and eye irritation is waived in accordance with REACH Annex XI. Data are available on one of the streams in this category (all CAS numbers are; 68476-52-8, 68477-42-9, 68955-28-2, 87741-01-3, 92045-23-3) and indicate that the irritation potential of this category is low. All members of this category are gases, and liquid gases may cause burns and frostbite due to the extreme cold of the liquid.
accordance with Section 2 of REACH Annex XI, studies on skin and eye
irritation do not need to be conducted as members of the C4 high
1,3-butadiene category (CAS numbers; 68476-52-8, 68477-42-9, 68955-28-2,
87741-01-3, 92045-23-3) are flammable gases at room temperature.
However, skin and
eye irritation studies have been conducted on one of the streams in this
Concentrate (CAS no. 68955-28-2) was not irritating to rabbit skin or
eyes (Mobil 1985). The available data on one of the component
substances,1,3-butadiene, also indicates that it is not irritating (EU
RAR, 2002).Humans exposed to1,3-butadiene
at 2000 ppm (4425 mg/m3) and 4000 ppm (8851 mg/m3)
described slight smarting of the eyes and difficulty in focusing
although at 8000 ppm (17,702 mg/m3) no subjective symptoms
were reported (Carpenter et al, 1944).Rapid
evaporation following application of these substances is likely so the
value of these studies is questionable. No data are available on the
other component substances (butene isomers and butane), but
based on physical chemical properties, the liquid gases may cause burns
and frostbite due to the extreme cold of the liquid. There are no
indications of irritation from repeat dose inhalation studies.
Effect level: empty Endpoint conclusion: Adverse
of the C4 high 1,3-butadiene category are flammable gases at room
temperature. There are sufficient data available to conclude that
streams within the C4 high 1,3-butadiene category are not irritating
therefore do not warrant classification under Dir 1999/45/EC or GHS/CLP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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