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EC number: 295-405-4
CAS number: 92045-23-3
A complex combination of hydrocarbons produced by the distillation of the products of a steam cracking process. It consists predominantly of hydrocarbons having a carbon number of C4, predominantly 1-butene and 2-butene, containing also butane and isobutene and boiling in the range of approximately minus 12°C to 5°C (10.4°F to 41°F).
data for the 1,3-butadiene surveillance group and the comparison group
for both plants combined.
White blood cells (103/mm3)
Red blood cells (103/mm3)
Hgb (g/100 ml)
Mean corpuscular volume (mm3)
Platelet count (103/mm3)
are means (N)
Means adjusted for age, race, sex, smoking status, first exam value, and
duration between first and last exams.
significantly different at p < 0.05, adjusted for multiple comparisons
using the Bonferroni method.
parameters were compared in workers at two 1,3-butadiene plants who had
participated in the Shell Butadiene Medical Surveillance Program from
1979 -2003 with a group of employees who had not participated in the
program and therefore were not exposed to 1,3-butadiene. Exposure data
showed that the 1,3-butadiene surveillance group for 1979-1996 had a
mean overall exposure of 4.55 ppm (10.07
10h and 12h-TWA); from 1997, this figure was 0.25 ppm (0.55 mg/m3).
Before 1996 the OSHA exposure
limit was 1000 ppm and post-1996 it was 1 ppm. Both facilities gave
similar exposure results. There were no significant differences in 6
Complete Blood Count parameters (white blood cell count, lymphocyte
count, red blood cell count, hemoglobin concentration, mean corpuscular
volume, and platelet count) between the 1,3-butadiene surveillance group
compared with the comparison group when compared on an individual plant
basis or all results combined. There was therefore no evidence of
adverse haematological findings associated with exposure to
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