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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Comparable to guideline study.
Reason / purpose for cross-reference:
reference to same study
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions) - Method B: Fibre Length and Diameter Distributions
Principles of method if other than guideline:
Methods for the determination of the hazardous properties for human health of man made mineral fibres (MMMF), (Report EUR 18748, 1999).
GLP compliance:
yes
Type of method:
microscopic examination
Type of particle tested:
other: fibre
Type of distribution:
other: not specified
Remarks on result:
not measured/tested
Key result
Percentile:
D50
Mean:
> 0.4 - < 0.8 µm
Remarks on result:
other: St Dev not given

AMD (µm): 0.53 -1.13

GMD (µm): 0.42 -0.8

D<1 µm: % 58 -90.7

D<2 µm: % 86.3 -98.7

D<3 µm: % 94.3 -99

AML (µm): 12.6 -18.16

GML (µm): 8.26 -11.45

L50 (µm): 7.7 -10.6

Size (µm) Distribution (%)
> 50 > 2 - < 8.7
> 30 - < 50 > 4 - < 9
> 15 - < 30 > 14.3 - < 21
> 5 - < 15 > 41.7 - < 52.3
< 5 > 18 - < 28.7
Conclusions:
Geometry of FMMVF fibres varies depending on the fibre type as presented below.

Parameter Unit Approximate range
L<5 μm % 18-28.7
51530L>50 μm % 2.7-8.7

Executive summary:

Geometry of FMMVF fibres is presented. The geometry depends on the substance type and an approximate range is presented in the below table.

Geometry of FMMVF fibres

Parameter

Unit

Approximate range

L<5 μm

%

18 - 28.7

5<L<15 μm

%

41.7 - 50.3

15<L<30 μm

%

14.3 - 21

30<L<50 μm

%

4 - 9

L>50 μm

%

2.7 - 8.7

Description of key information

It is shown that the geometry of FMMVF fibres varies depending on the fibre type. Fibre length and fibre thickness are the most important parameters related to the fibre granulometry. For commercial fibres the average fibre length (mm) range is 1.05 -1.52; max fibre length (mm) is 6.9 -17.2 and the fibre thickness varies within the range of 0.7 - 6 µm. The fibres described in Cullen et al 2000 showed diameters <0.1µm to 0.9 µm, with more than 60% between 0.2 µm to 0.4 µm.
Length weighted arithmetic thickness: Average (D): 4.39 µm, 4.27 µm, 3.86 µm
Length weighted geometric thickness: Average (Dg): 3.86 µm, 3.78 µm, 3.48 µm

Additional information

Information from a comparable to guideline study on the particle size distribution of FMMVF fibres. Particle size distribution of the fibres specifically prepared for a carcinogenicity study is presented.

Particle size of the fibres specifically prepared for a carcinogenicity study is presented below. It is noted that the data presented below is not representative of the commercial material.

Additional data on particle size distribution is given under End point study 7.5.3 Repeated dose Toxicity: inhalation.McConnell et al 1994, and 7.7 Carcinogenicity Cullen et al 2000.

Geometry of FMMVF fibres

Parameter

Unit

Approximate range

L<5 μm

%

18-27

5<L<15 μm

%

43-52

15<L<30 μm

%

17-19

30<L<50 μm

%

6-9

L>50 μm

%

2-9