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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in mammalian cells
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion

Conclusions:
Long-term inhalation carcinogenicity studies (24 months) showed limited evidence of carcinogenicity by FMMVF fibres. Furthermore, FMMVF fibres are inorganic fibres, whose physicochemical properties suggest a low potential to cross biological membranes, making it unlikely that a mutagenic effect would be found in bacteria. FMMVF fibres are assessed to possess no mutagenic properties in bacteria.
Executive summary:

Long-term inhalation carcinogenicity studies (24 months) showed limited evidence of carcinogenicity by FMMVF fibres. Furthermore, FMMVF fibres are inorganic fibres, whose physicochemical properties suggest a low potential to cross biological membranes, making it unlikely that a mutagenic effect would be found in bacteria. FMMVF fibres are assessed to possess no mutagenic properties in bacteria.