Registration Dossier

Diss Factsheets

Physical & Chemical properties

Dissociation constant

Currently viewing:

Administrative data

Link to relevant study record(s)

Referenceopen allclose all

Endpoint:
dissociation constant
Type of information:
other: Bibliographic peer reviewed data
Adequacy of study:
weight of evidence
Study period:
1985
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Qualifier:
no guideline followed
Principles of method if other than guideline:
not applicable
GLP compliance:
not specified
Dissociating properties:
yes
No.:
#1
pKa:
3.3
Temp.:
25 °C

The acid-base constant of Glyoxylic Acid is 3.3

Executive summary:

The acid-base constant of Glyoxylic Acid is 3.3 as reported in Lange´s Handbook of Chemistry.

Endpoint:
dissociation constant
Type of information:
other: Handbook
Adequacy of study:
weight of evidence
Study period:
1989
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Qualifier:
no guideline followed
Principles of method if other than guideline:
not applicable
GLP compliance:
not specified
Dissociating properties:
yes
No.:
#1
pKa:
4.7
Temp.:
25 °C
Executive summary:

The acid-base constant of Glyoxylic Acid 50% is 4.7, based on literature data from Ullmann´s encyclopedia.

Endpoint:
dissociation constant
Type of information:
other: handbook
Adequacy of study:
weight of evidence
Study period:
1996
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Qualifier:
no guideline available
Principles of method if other than guideline:
not applicable
GLP compliance:
not specified
Dissociating properties:
yes
No.:
#1
pKa:
4.6
Temp.:
25 °C

The acid-base constant of Glyoxylic Acid is 4.6.

Executive summary:

The acide base constant of Glyoxylic Acid is 4.6 as reported in the Merck Index.

Endpoint:
dissociation constant
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
QSAR prediction
Qualifier:
no guideline followed
Principles of method if other than guideline:
Calculation by using SPARC Performance Automated Reasoning in Chemistry (Release w4.5.1529-s4.5.1529; september 2009)
GLP compliance:
not specified
Dissociating properties:
yes
No.:
#1
pKa:
3.12
Temp.:
25 °C
Executive summary:

By using SPARC Performance Automated Reasoning in Chemistry (V 4.2) the dissociation constant of Glyoxylic Acid was calculated and resulted in pKa of 3.12. For detailed information on the dissociation properties of Glyoxylic Acid see attached file.

Description of key information

The dissociation constant of Glyoxylic Acid 50% is in the range from  3.12-4.7.

Key value for chemical safety assessment

Additional information

Data on the dissociation constant of Glyoxylic Acid 50% is available from handbook literature and values of 3.3, 4.6 and 4.7 are reported. Additionally the dissociation constant of Glyoxylic Acid 50% was calculated as 3.12 by using SPARC Performance Automated Reasoning in Chemistry (V 4.2). The calculated value for the dissociation constant is in line with the reported values from handbook data.