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Diss Factsheets

Administrative data

Endpoint:
hydrolysis
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance is readily biodegradable
Cross-reference
Reason / purpose for cross-reference:
data waiving: supporting information
Reference
Endpoint:
biodegradation in water: ready biodegradability
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 18. May to 02. June 2009
Reliability:
1 (reliable without restriction)
Qualifier:
according to guideline
Guideline:
OECD Guideline 301 A (Ready Biodegradability: DOC Die Away Test)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
Harlan Laboratories Ltd., Quality Assurance GLP, Zelgliweg 1, 4452 Itingen, Switzerland
Oxygen conditions:
aerobic
Inoculum or test system:
activated sludge, domestic, non-adapted
Details on inoculum:
- Source of activated sludge:
wastewater treatment plant (ARA Ergolz II, Füllinsdorf / Switzerland) treating predominantly domestic wastewater
- Storage conditions:
room temperature
- Pretreatment:
The sludge was washed twice with tap water by centrifugation and the supernatant liquid phase was decanted. A homogenized aliquot of
the final sludge suspension was weighed, thereafter dried and the ratio of wet to dry weight was calculated
- Concentration of sludge:
30 mg dry material per liter
Duration of test (contact time):
14 d
Initial conc.:
30.4 mg/L
Based on:
DOC
Parameter followed for biodegradation estimation:
DOC removal
Reference substance:
benzoic acid, sodium salt
Parameter:
% degradation (DOC removal)
Value:
98
St. dev.:
2.8
Sampling time:
3 d
Validity criteria fulfilled:
yes
Interpretation of results:
readily biodegradable
Conclusions:
Due to the fact that > 98 % of Glyoxylic Acid 50 % were degraded within the 10-d window of the incubation period, the test item can be classified as readily biodegradable under the conditions of this study.
Executive summary:

In a Ready Biodegradability study (OECD 301 A) Glyoxylic Acid 50% was assessed over a 14 day period by the DOC die away test. The nominal test concentration was 30.4 mg/L. The test material attained > 98 % biodegradation after 3 and 10 days, respectively. The reference compound sodium benzoate showed a mean biodegradability of > 90 % within 7 days, thus confirming suitability of the activated sludge.

These results indicate that Glyoxylic Acid 50% is readily biodegradable under conditions of the test.

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion