Registration Dossier

Administrative data

Endpoint:
dermal absorption
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Studies based on which the toxicokinetic behaviour of the substance can be derived, considered acceptable for assessment. Also peer-reviewed under Regulation 793/93.

Data source

Reference
Reference Type:
other: EU Risk Assessment Report (RAR)
Title:
Trichloroethylene
Author:
Rapporteur: United Kingdom, on behalf of the European Union
Year:
2004

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Test animals

Species:
other: mice and guinea pigs

Results and discussion

Absorption in different matrices:
The results of these dermal studies suggest that both liquid trichloroethylene and trichloroethylene in aqueous solution is well absorbed. There are no data on the dermal uptake of trichloroethylene from the vapour phase. Although no studies of metabolism, distribution or
elimination have been conducted in animals exposed to trichloroethylene by the dermal route, there is no evidence to suggest that it is different from that described for oral and inhalation exposures.
Results of invitro studies: These two studies suggest that rat and guinea pig lungs are more efficient at onwards metabolism of chloral hydrate from trichloroethylene than mouse lung Clara cells.

Applicant's summary and conclusion