Registration Dossier
Registration Dossier
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EC number: 201-167-4 | CAS number: 79-01-6
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Studies based on which the toxicokinetic behaviour of the substance can be derived, considered acceptable for assessment. Also peer-reviewed under Regulation 793/93.
Data source
Reference
- Reference Type:
- other: EU Risk Assessment Report (RAR)
- Title:
- Trichloroethylene
- Author:
- Rapporteur: United Kingdom, on behalf of the European Union
- Year:
- 2 004
Materials and methods
- Principles of method if other than guideline:
- Toxicokinetic studies
Test material
- Reference substance name:
- Trichloroethylene
- EC Number:
- 201-167-4
- EC Name:
- Trichloroethylene
- Cas Number:
- 79-01-6
- Molecular formula:
- C2HCl3
- IUPAC Name:
- 1,1,2-trichloroethene
- Reference substance name:
- trichloroethene
- IUPAC Name:
- trichloroethene
Constituent 1
Constituent 2
Administration / exposure
- Route of administration:
- other: Oral and Inhalation
Results and discussion
Main ADME results
- Type:
- other: see summary of studies in attachment
- Results:
- Studies in experimental animals have shown that trichloroethylene is rapidly and extensively absorbed by all routes of exposure. Once absorbed it readily distributes to all compartments within the body.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
