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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Studies with regard to acute oral toxicity, acceptable for assessment, also peer-reviewed under Regulation 793/93.

Data source

Reference
Reference Type:
other: EU Risk Assessment Report (RAR)
Title:
Trichloroethylene
Author:
Rapporteur: United Kingdom, on behalf of the European Union
Year:
2004

Materials and methods

Test type:
other:

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Test animals

Species:
other: guinea pig, rabbit
Strain:
not specified

Administration / exposure

Type of coverage:
other: occlusive & semiocclusive
Vehicle:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 20 000
Based on:
other: rabbit

Applicant's summary and conclusion

Conclusions:
The LD50 value of trichloroethylene in rabbits when administered by the dermal route, using an occlusive dressing, has been reported as being greater than 29000 mg/kg body weight .
In another study, the LD50 value in the rabbit following a 24-hour exposure with a semi-occlusive dressing was reported to be > 20000 mg/kg.
No deaths occurred in guinea-pigs following dermal
application of 7800 mg/kg body weight of trichloroethylene using a similar method: the only sign of toxicity noted was reduced weight gain during the 35-day post-exposure observation period.