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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
review article or handbook
Title:
Evaluation of the cutaneous irritation potential of 56 compounds
Author:
Guillot J.P., Gonnet J.F., Clement C.
Year:
1982
Bibliographic source:
Food and Chemical Toxicology, 20

Materials and methods

Principles of method if other than guideline:
According to OECD 404
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Strain:
other: New Zeland strain
Details on test animals and environmental conditions:
No data

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
other: The substance was applied in ganze pads
Controls:
no
Amount / concentration applied:
Animals were exposed to 0.5 g of the substance for 4 hours.
Duration of treatment / exposure:
4 h
Observation period:
1, 24, 48, 72 h
Number of animals:
6

Results and discussion

In vivo

Results
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Time point:
other: 2
Score:
ca. 0.04
Reversibility:
fully reversible within: 24h
Irritant / corrosive response data:
Disodium hexafluorosilicate does not show irritating effects.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
After 14 days no signs of irritation on skin were evident. Thus, this substance cannot be classified as irritating.