Registration Dossier

Administrative data

Description of key information

Reliable information on acute inhalation toxicity indicates that the substance shall be classified according to in force regulations. Some non-standard acute oral toxicity studies as well as information on structurally related substance are available and are reported. This data also indicates that the substance shall be classified according to in force regulations. Waivers are appropriate for acute dermal toxicity as it is not a relevant exposure route. 

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
70 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
LC50
Value:
1 814 mg/m³

Additional information

Acute oral toxicity

 

As quite little information on this substance is available, read-across from structural analogues based on fluorides has been carried out. LD50 values obtained for fluorides are in the range of 44-114 mg/bw. These values obtained for this substance indicate that LD50 value is of 70 mg/bw. As it is within the range of those found for fluorides, this value is used for CSA

 

Acute inhalation toxicity

 

A study performed by the registrant in 2010 has clearly shown that LD50 for male and female is 1.841 mg/L. However, symptoms appeared when the animals were doses 0.45 mg/L, having this value been established as LOAEC.

 

Acute dermal toxicity

 

Information available on this endpoint does not indicate that the substance does cause any harm. However, as dermal is not considered a relevant route of exposure, a waiver is appropriate for this endpoint.

Justification for classification or non-classification

This substance is classified according to the CLP Regulation (EC) 1272/2008 in Acute Toxicity Category 3 (H301, H311, H331). This classification is consistent with the data reviewed and no change is proposed.