Registration Dossier

Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
review article or handbook
Title:
Mutagenicity of cosmetics ingredients licensed by European Communities
Author:
Gocke E, King MT, Eckhardt K, Wild D. Mutat
Year:
1981
Bibliographic source:
Mutation Research, 90, (1981),

Materials and methods

Test guideline
Guideline:
OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
GLP compliance:
not specified
Type of assay:
other: Micronucleus test

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
other: Mice and rats
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Details on exposure:
No data
Duration of treatment / exposure:
Animals were exposed up to 24 h
Doses / concentrations
Remarks:
Doses / Concentrations:
Doses: 37.2 mg/kg; 0.198 mmol/kg
Basis:

Results and discussion

Applicant's summary and conclusion