Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
review article or handbook
Title:
Mutagenicity of cosmetics ingredients licensed by European Communities
Author:
Gocke E, King MT, Eckhardt K, Wild D. Mutat
Year:
1981
Bibliographic source:
Mutation Research, 90, (1981),

Materials and methods

Test guideline
Guideline:
OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
GLP compliance:
not specified
Type of assay:
other: Micronucleus test

Test material

Constituent 1
Chemical structure
Reference substance name:
Disodium hexafluorosilicate
EC Number:
240-934-8
EC Name:
Disodium hexafluorosilicate
Cas Number:
16893-85-9
Molecular formula:
F6Si.2Na
IUPAC Name:
disodium hexafluorosilicate

Test animals

Species:
other: Mice and rats
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Details on exposure:
No data
Duration of treatment / exposure:
Animals were exposed up to 24 h
Doses / concentrations
Remarks:
Doses / Concentrations:
Doses: 37.2 mg/kg; 0.198 mmol/kg
Basis:

Results and discussion

Applicant's summary and conclusion