Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 240-934-8 | CAS number: 16893-85-9
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Mutagenicity of cosmetics ingredients licensed by European Communities
- Author:
- Gocke E, King MT, Eckhardt K, Wild D. Mutat
- Year:
- 1 981
- Bibliographic source:
- Mutation Research, 90, (1981),
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- GLP compliance:
- not specified
- Type of assay:
- other: Micronucleus test
Test material
- Reference substance name:
- Disodium hexafluorosilicate
- EC Number:
- 240-934-8
- EC Name:
- Disodium hexafluorosilicate
- Cas Number:
- 16893-85-9
- Molecular formula:
- F6Si.2Na
- IUPAC Name:
- disodium hexafluorosilicate
Constituent 1
Test animals
- Species:
- other: Mice and rats
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Details on exposure:
- No data
- Duration of treatment / exposure:
- Animals were exposed up to 24 h
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Doses: 37.2 mg/kg; 0.198 mmol/kg
Basis:
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
