Registration Dossier
Registration Dossier
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EC number: 213-424-8 | CAS number: 947-04-6
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- repeated dose toxicity: inhalation, other
- Remarks:
- other: 5 day repeated inhalation test
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1964
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: No analytical monitoring; significant methodological deficiencies
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1964
Materials and methods
- Principles of method if other than guideline:
- see Test Conditions
- GLP compliance:
- no
Test material
- Reference substance name:
- Dodecane-12-lactam
- EC Number:
- 213-424-8
- EC Name:
- Dodecane-12-lactam
- Cas Number:
- 947-04-6
- Molecular formula:
- C12H23NO
- IUPAC Name:
- 1-azacyclotridecan-2-one
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- other: 20 mice, 10 rats, 2 guinea pigs, 1 rabbit, 1 cat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- Animals were exposed in a 400 l room to the vapours of the test substance that were generated by heating 20 g of test substance at 160 °C.
The average loss of test substance during the daily exposure was 11.4 g. - Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 5 days
- Frequency of treatment:
- 4 hours/day
- No. of animals per sex per dose:
- 20 mice, 10 rats, 2 guinea pigs, 1 rabbit, 1 cat (sex not reported)
- Control animals:
- no
- Details on study design:
- Post-exposure period: 14 days
- Positive control:
- none
Examinations
- Observations and examinations performed and frequency:
- no details reported
- Sacrifice and pathology:
- no data
- Statistics:
- no data
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Mortality:
- mortality observed, treatment-related
- Body weight and weight changes:
- not examined
- Food consumption and compound intake (if feeding study):
- not examined
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- not examined
- Clinical biochemistry findings:
- not examined
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- not examined
- Gross pathological findings:
- not examined
- Histopathological findings: non-neoplastic:
- not examined
- Histopathological findings: neoplastic:
- not examined
- Details on results:
- Except for minor signs of irritancy of the mucosa of nose, throat, and eyes, no signs of intoxication were observed.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
