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EC number: 213-424-8 | CAS number: 947-04-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
see "Additional information"
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Renal excretion of lauryl lactam could be demonstrated in a follow up study of the 90 day oral repeated dose toxicity study (SANOFI, 1993). Urine samples (5 ml/animal) were collected from 5 animals/sex/group on days 45 and 85 from the rats 90 day oral repeated dose toxicity study (Arkema, 2009) and quantification of lauryl lactam via gas chromatography-flame ionization detector was performed in urine samples on 5 males and 4 females of the highest dose group (125 mg/kg/day; Arkema, 2009). Lauryl lactam could be detected in these examined urine samples. There is no further information available on toxicokinetics, metabolism or distribution of lauryl lactam.
The structurally related compound ε-caprolactam was examined regarding toxicokinetics in male, female and pregnant female mice (Waddell et al., 1984).
After oral or i.v. administration of
radioactive labelled ε-caprolactam
the substance was rapidly absorbed and distributed throughout the
animals including the foetuses. There was no retention of radioactivity
observed in foetuses.
No differences in pattern of distribution among male, non-pregnant and
pregnant mice could be detected. The substance ε-caprolactam
is rapidly eliminated by renal and hepatic routes. Metabolism in liver
prior to secretion into bile seems likely.There are indications that
enterohepatic circulation is absent. Because of structural similarities
between ε-caprolactam
and lauryl lactam it is assumed that lauryl lactam shows similar
toxicokinetic behaviour.
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