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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1973
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report date:
1973

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not specified
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chlorobenzonitrile
EC Number:
212-836-5
EC Name:
2-chlorobenzonitrile
Cas Number:
873-32-5
Molecular formula:
C7H4ClN
IUPAC Name:
2-chlorobenzonitrile
impurity 1
Reference substance name:
unknown
IUPAC Name:
unknown
Test material form:
solid

Test animals

Species:
rat
Strain:
Wistar
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: sesame oil
Doses:
125, 200, 320, 500 and 800 mg/kg bw
No. of animals per sex per dose:
10 f
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
396 mg/kg bw
Based on:
test mat.
95% CL:
>= 321 - <= 488
Clinical signs:
jerkingly breathing, vestibular disorder, lateral or abdominal position

Any other information on results incl. tables

Dose [mg/kg bw]

Concentration [%]

Dead animals per dose group

125

1

0 of 10 rats

200

4

1 of 10 rats

320

4

3 of 10 rats

500

4

6 of 10 rats

800

4

10 of 10 rats

 

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The LD50 of o-Chlorobenzonitrile administered to female rats is 396 mg/kg bw.
Executive summary:

2-chlorobenzonitrile was administered by gavage in a single dose of 125, 200, 320, 500 and 800 mg/kg to 10 female rats per dose. Animals were observed for 14 consecutive days. Mortality occurred in the test groups receiving >= 200 mg/kg bw.

The LD50 was calculated to be 396 mg/kg bw.