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EC number: 212-836-5
CAS number: 873-32-5
elicited by 2-Chlorobenzonitrile
Rabbit Number and sex
Region of Eye
Day after instillation
In a GLP guideline study according to OECD 405 (1987) 0.1 ml
(approx. 90 mg) 2-Chlorobenzonitrile was installed into the lower
everted eye lid of one eye of each of 3 female New Zealand White
rabbits. Examination of the eyes was made after 1 hour and 1, 2, 3, 4
and 7 days after instillation. All animals were observed daily for signs
of ill health or toxic signs.The test material elicited transient,
corneal opacification and temporary well-defined conjunctival reactions.
Two of three animals show corneal effects >=1 after 24 -72h. Based
on the scoring result the classification “H319: Causes serious eye
irritation” is warranted.
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