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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
27th June 2011 to 21st July 2011
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: A GLP compliant study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
yes
Remarks:
The test was repeated as analytical recovery rates were insufficient (62.5 to 71.6%) when using cyclohexane as extraction solvent. Only the results of the second successful test are reported.
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
yes
Remarks:
The test was repeated as analytical recovery rates were insufficient (62.5 to 71.6%) when using cyclohexane as extraction solvent. Only the results of the second successful test are reported.
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Deviations:
yes
Remarks:
The test was repeated as analytical recovery rates were insufficient (62.5 to 71.6%) when using cyclohexane as extraction solvent. Only the results of the second successful test are reported.
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Specific details on test material used for the study:
- Name of test material (as cited in study report): 1-phenylethyl acetate
- Physical state: colourless to pale yellow liquid
- Name of test material (as cited in study report): Gardenol
- Lot/batch No.: VE00123242
- Expiration date of the lot/batch: 14th January 2013
Water solubility:
1.27 g/cm³
Temp.:
20 °C
pH:
ca. 7
Details on results:
Slightly higher solubility was noted in ISO medium compared to water, this was not considered to be significant.

Table 1: Results

   Contact time (h)        
 Concentration (g/L)  24  48  72  Average
 Water, average  1.30  1.27  1.23  1.27
 ISO medium, average  1.29  1.30  1.26  1.28

The pH values of the solutions in ultrapure water and ISO medium were both approximately pH 7.

Conclusions:
Interpretation of results (migrated information): soluble (1000-10000 mg/L)Under the conditions of the test, the water solubility of the test substance was determined to be 1.27 g/L at 20ºC.
Executive summary:

In a GLP compliant water solubility study conducted in line with standardised guidelines OECD 105, EU Method A.6 and EPA OPPTS 830.7840, the water solubility of the test substance was determined using the flask method. The water solubility of the substance was determined to be 1.27 g/L at 20ºC.

Description of key information

The water solubility of 1-phenylethyl acetate was determined to be 1.27 g/L at 20ºC according to a study performed in line with OECD Guideline 105, EU Method A.6 and EPA OPPTS 830.7840. 

Key value for chemical safety assessment

Water solubility:
1.27 g/L
at the temperature of:
20 °C

Additional information

The key study (Givaudan, 2011e) was conducted in line with GLP and standardised guidelines with a sufficient level of detail to assess the quality of the study. The study was performed to a good standard and was assigned a reliability score of 1 in accordance with Klimisch (1997).