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EC number: 202-288-5 | CAS number: 93-92-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not stated
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in accordance with generally accepted scientific principles following a protocol for the assessment of sensitisation in humans.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Kligman (1966) The Identification of Contact Allergens by Human Assay III. The Maximization Test: A Procedure for Screening and Rating Contact Sensitisers The Journal of Investigative Dermatology 47(5): 393-409
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-phenylethyl acetate
- EC Number:
- 202-288-5
- EC Name:
- 1-phenylethyl acetate
- Cas Number:
- 93-92-5
- Molecular formula:
- C10H12O2
- IUPAC Name:
- 1-phenylethyl acetate
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: 1-phenylethyl acetate- Name of test material (as cited in study report): Methyl Phenyl Carbinyl Acetate
Method
- Type of population:
- general
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed: 25- Sex: male- Age: 21-56
- Clinical history:
- Volunteers were described as healthy, no further information was provided.
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: patch test (epicutaneous test)ADMINISTRATION- Type of application: occlusive- Vehicle / solvent: petrolatum N.F.- Concentrations: 4%
Results and discussion
- Results of examinations:
- No reactions were observed in any of the subjects at either observation time.
Any other information on results incl. tables
Table 1: Grading scale results
Subject number | 48 hours | 72 hours |
1 | 0 | 0 |
2 | 0 | 0 |
3 | 0 | 0 |
4 | 0 | 0 |
5 | 0 | 0 |
6 | 0 | 0 |
7 | 0 | 0 |
8 | 0 | 0 |
9 | 0 | 0 |
10 | 0 | 0 |
11 | 0 | 0 |
12 | 0 | 0 |
13 | 0 | 0 |
14 | 0 | 0 |
15 | 0 | 0 |
16 | 0 | 0 |
17 | 0 | 0 |
18 | 0 | 0 |
19 | 0 | 0 |
20 | 0 | 0 |
21 | 0 | 0 |
22 | 0 | 0 |
23 | 0 | 0 |
24 | 0 | 0 |
25 | 0 | 0 |
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of the test, 4% test substance did not produce any cases of contact allergy in twenty-five adult males.
- Executive summary:
In a pre-GLP human bioassay study conducted in line with the Maximisation test for identifying contact allergens in humans, 4% of the test material in petrolantum N.F. was applied under occlusion to the forearms of 25 male volunteers age 21 to 56 for 48hrs. After a 10 day rest period challenge patches were applied under occlusion to fresh sites on the the shoulder area of the backs for 48hrs. Reactions were read on patch removal and 24hrs after the patch removal. Under the conditions of this test, the test material, 1-phenylethyl acetate at 4% was determined not to cause contact allergy.
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