2-(octylthio)ethanol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

01-1957 to 03-1957

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Limited information on the test substance, animals tested/environmental conditions, examinations performed, and exposure apparatus were provided. No necropsies were performed. No information on the dosage level tested (study did state treated air approached saturation with test substance), and only six males were tested. Not GLP.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1957

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: recommendations outlined by the National Safety Council

GLP compliance:

no

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

2-(octylthio)ethanol

EC Number:

222-598-4

EC Name:

2-(octylthio)ethanol

Cas Number:

3547-33-9

Molecular formula:

C10H22OS

IUPAC Name:

2-(octylsulfanyl)ethan-1-ol

Constituent 2

Reference substance name:

Ethanol, 2-(octythio)-

IUPAC Name:

Ethanol, 2-(octythio)-

Constituent 3

Reference substance name:

2-hydroxyethyl-n-octyl sulfide

IUPAC Name:

2-hydroxyethyl-n-octyl sulfide

Details on test material:

- Name of test material (as cited in study report): 2-Hydroxyethyl-n-octyl sulfide
- Substance type: Active
- Physical state: Colorless liquid

Test animals

Species:

rat

Strain:

other: Albino

Sex:

male

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

not specified

Vehicle:

other:

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Method of conditioning air: Dried air was passed through the fritted disc of a gas washing bottle initially at room temperature.

Analytical verification of test atmosphere concentrations:

not specified

Concentrations:

No data-Study stated that the animals were exposed to a stream of air approaching saturation with the test substance.

No. of animals per sex per dose:

6 males

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The rats were closely observed throughout the exposure period and during the 14 days post exposure.
- Necropsy of survivors performed: no
- Other examinations performed: mortality, symptoms of irritation, irregular respirations, or stages of narcosis

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LC50

Effect level:

ca. 100 other: % vapors

Based on:

test mat.

Mortality:

All six rats survived the 8-hour exposure.

Clinical signs:

other: Animals showed no signs of irritation or objection to the vapor during exposure.

Body weight:

There was an average body weight gain of 62 g.

Applicant's summary and conclusion

Conclusions:

There were no deaths recorded during or 14 days following an 8-hour exposure of male albino rats to concentrate vapors.

Executive summary:

Six albino rats that were exposed to a stream of air approaching saturation with vapors of ethanol, 2-(octylthio) for 8 hours. The rats were observed throughout the exposure for mortality, symptoms of irritation, irregular respirations, or stages of narcosis. Although dose level was not provided, all 6 rats survived to the end of the 14-day observation period, and no animals showed signs of irritation or objection to the vapor during the exposure.