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Administrative data

Description of key information

ACUTE ORAL toxicity LD50 value (mg/kg): >5000 
ACUTE DERMAL toxicity LD50 value (mg/kg): >2000
ACUTE INHALATION toxicity 4-hour rat LC50 value (mg/L): >6.12 (aerosol)

Key value for chemical safety assessment

Additional information

The lowest reported oral LD50 is >5000 mg/kg in rats. One female was found dead on Day 2. Clinical signs observed in both sexes were ruffled fur, diarrhea, dark stained muzzle, and anogenital staining. By Day 6, all rats recovered from the above conditions and appeared active and healthy for the remainder of the 14-day observation period. No treatment-related gross pathology was observed at termination (US EPA 1995). In the other acute oral toxicity study in rats, the oral LD50 is 8530 mg/kg. The rats in all but the lowest dose group became sick and ataxic immediately following oral administration of the test substance. All of the rats died in the two highest dose levels (15.8 and 31.6 mg/kg). The surviving rats in the two lower dose groups (3.98 and 7.95 mg/kg) were sluggish the first day but recovered fully thereafter and showed good weight gains during the 14 -day observation period. No treatment-related gross pathology was observed in the surviving animals at termination. (Industrial Hygiene Foundation America, Inc., 1957).

A dermal LD50 of >2000 mg/kg was determined for rabbits. Well defined erythema with severe edema and eschar at 4 days. Body weight loss was seen in 4/5 males and 4/5 females on Day 7, and in 2/5 males and 4/5 females on Day 14. Decreases in body weight gain were seen in 2/5 males and 4/5 females during the 14 day period. While no clinical signs were seen in males, 1-4 females exhibited tremors, lethargy, signs of diarrhea, no feces or thin appearance on Days 6 through 14. Gross necropsy revealed a lower gastrointestinal tract full of gas, mucus and dark liquid in two males and three females. The results of this study determined that the acute dermal LD50 was greater than 2000 mg/kg for both sexes (U.S. EPA, 1995).

Sprague-Dawley rats (5/sex) were exposed to aerosol concentrations of undiluted technical hydroxyethyl octyl sulfide (96.1%) at a mean analytical concentration of 6.12 ± 0.16 mg/L with a mass median aerodynamic diameter (MMAD) particle size distribution of 2.0 ± 0.03 μM for 4 hours. The acute inhalation LC50 was >6.12 mg/L for both sexes (U.S. EPA, 1995).

Justification for classification or non-classification

Acute Oral

Classification proposal regarding acute oral toxicity: DSD: None. GHS/CLP: None.

Acute Inhalation

Classification proposal regarding acute inhalation toxicity: DSD: None. GHS/CLP: None.  

Acute Dermal

Classification proposal regarding acute dermal toxicity: DSD: None. GHS/CLP: None.