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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Description of key information

Key value for chemical safety assessment

Justification for classification or non-classification

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Some data on carcinogenic potential of the test substance can be found in literature (Scientific Committee on Occupational Exposure Limits (SCOEL), SCOEL/SUM/178, September 2010).


In a carcinogenicity oral study at estimated daily doses of 42 to 46 mg/kg bw, no significant occurrences of tumor were recorded. No control group was described in this study.

Although reliability of these data are limited, they indicate that chronic exposure of rats to the test substance shows no high carcinogenic potential.


In another study at estimated daily doses of 35 mg/kg bw during approximately 200 days, occurrences of tumors were significantly increased in mice exposed to the test substance together with sodium nitrite in drinking water. It was concluded that the combination of test substance in food with sodium nitrite in drinking water led to the formation of carcinogenic nitrosamines.

Due to the relatively short duration of exposure and the limited number of groups no conclusive decision can be drawn with respect to carcinogenicity of the test substance other than that sub-chronic exposure of mice to test substance shows no high carcinogenic potential.