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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
sub-chronic toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Collection of data by the Scientific Committee on Occupational Exposure Limits, a committee of the European Commission established in 1995 to advise on occupational exposure limits for chemicals in the workplace within the framework of Directive 98/24/EC, the chemical agents directive; and Directive 90/394/EEC, the carcinogens at work directive.

Data source

Reference
Reference Type:
review article or handbook
Title:
Handbook of Intermediary Metabolism of Aromatic CompoundsRecommendation from the Scientific Committee on Occupational Exposure Limits for N-methylaniline
Author:
Scientific Committee on Occupational Exposure Limits
Year:
2010
Bibliographic source:
Scientific Committee on Occupational Exposure Limits (SCOEL), SCOEL/SUM/178, September 2010.

Materials and methods

Principles of method if other than guideline:
Tests were performed before the existence of international guidelines, reference: Treon, J.F. et al., 1950. The toxic properties of xylidine and monomethylaniline II. Arch. of industrial hygiene & occupational medicine Vol. 1, pages: 506-524.
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
N-methylaniline
EC Number:
202-870-9
EC Name:
N-methylaniline
Cas Number:
100-61-8
Molecular formula:
C7H9N
IUPAC Name:
N-methylaniline

Test animals

Species:
other: Rabbits, rats, guinea pigs, cats, dogs and monkeys.
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
air
Remarks on MMAD:
MMAD / GSD: Not applicable.
Analytical verification of doses or concentrations:
no
Duration of treatment / exposure:
Different durations of exposure.
Frequency of treatment:
7h/d, 5d/week.
Doses / concentrations
Remarks:
Doses / Concentrations:

Basis:

No. of animals per sex per dose:
Not specified.
Control animals:
not specified

Results and discussion

Effect levels

Dose descriptor:
NOEC
Effect level:
10.7 mg/m³ air
Based on:
test mat.
Sex:
not specified
Basis for effect level:
other: Clinical signs of intoxication.

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion