Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-870-9 | CAS number: 100-61-8
Categories
- Category name:
- benzenamines
Justifications and discussions
- Category definition:
- benzenamines, if applicable methylated at the nitrogen and not at the benzene ring: aniline, N-methylaniline, N,N-dimethylaniline
- Category description:
- N-N-dimethylaniline, N-methylaniline, aniline (order of metabolic degradation)
- Category rationale:
- According to the OECD-Toolbox aniline is categorized under Phenols and Anilines and the other molecules defined as basesurface narcotics (OASIS Acute Toxicity MOA). A substance arrives often at that category when the target chemical does not fit in any other categories, so there may be no experimental evidence for this category. Therefore it was decided to form a specific group name for these molecules, i.e. benzenamines. The molecules selected here are further specified as methylated at the nitrogen and not at the benzene ring. They share the benzene and amine groups, and the amine group is bound to carbon at a primair, secundair or tertiair level. Further, the molecules are related at a metabolic level: N-methylaniline being an optional metabolite/degradation product of N-N-dimethylaniline and aniline being an optional metabolite/degradation product of both N-methylaniline and N-N-dimethylaniline.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
