N-methylaniline

Sensitisation data (human)

Administrative data

Endpoint:

sensitisation data (humans)

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

Reference from collection of data in review article.

Data source

Reference

Reference Type:

review article or handbook

Title:

Aniline—A ‘Historical’ Contact Allergen? Current Data from the IVDK and Review of the Literature

Author:

Uter W., Stropp G., Schnuch A. and Lessmann H.

Year:

2007

Bibliographic source:

Ann. Occup. Hyg., Vol. 51, No. 2, pp. 219–226

Materials and methods

Type of sensitisation studied:

skin

Study type:

other: Study on patients with dermatitis and already sensitized to p-phenylenediamine.

Test guideline

Qualifier:

no guideline required

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

N-methylaniline

EC Number:

202-870-9

EC Name:

N-methylaniline

Cas Number:

100-61-8

Molecular formula:

C7H9N

IUPAC Name:

N-methylaniline

Method

Type of population:

other: 160 patients with contact allergy to p-phenylenediamine

Controls:

Not included, reaction to test substance was compared to reaction to other anilines.

Route of administration:

dermal

Results and discussion

Results of examinations:

None of 40 patients positive when tested with 5% test substance and N,N-dimethylaniline; 37/58 patients positive when tested with 2% p-toluidine.

Applicant's summary and conclusion

Conclusions:

In contrast to 4-methylaniline, test substance did not induce an allergic reaction in patients hypersensitive to p-phenylenediamine.