N-methylaniline

Short-term toxicity to fish

Administrative data

Endpoint:

short-term toxicity to fish

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Study period:

1986

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: 2e. Study well documented, meets generally accepted scientific principles

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1986

Report date:

1986

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Test method according to Könemann H., 1981. Fish toxicity tests with mixtures of more than two chemicals: A proposal for a quantitative approach and experimental results. Toxicology Volume 19, Issue 3, 1981, Pages 229-238.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Aniline

EC Number:

200-539-3

EC Name:

Aniline

Cas Number:

62-53-3

Molecular formula:

C6H7N

IUPAC Name:

aniline

Constituent 2

Reference substance name:

2-methylaniline

IUPAC Name:

2-methylaniline

Constituent 3

Reference substance name:

3-methylaniline

IUPAC Name:

3-methylaniline

Constituent 4

Reference substance name:

4-methylaniline

IUPAC Name:

4-methylaniline

Details on test material:

Aniline: purity = pro analysis; LogPoct=1.03 (0.90); Mol weight= 93.13;Chs= 0.00
2-methylaniline: purity >= 99.5%; LogPoct=1.54; Mol weight= 107.16;Chs= 0.10
3-methylaniline: purity >= 99%; LogPoct=1.54; Mol weight= 107.16;Chs= - 0.07
4-methylaniline: purity > 97%; LogPoct=1.54; Mol weight= 107.16;Chs= -0.17
Chs: Hammett sigma constant, which is dependent on the position of the substituent.

Sampling and analysis

Analytical monitoring:

no

Test solutions

Vehicle:

yes

Test organisms

Test organisms (species):

Poecilia reticulata

Study design

Test type:

semi-static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

14 d

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

14 d

Dose descriptor:

LC50

Effect conc.:

125.6 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other: Aniline

Effect concentrations 2

Duration:

14 d

Dose descriptor:

LC50

Effect conc.:

81.3 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other: 2-Methylaniline

Effect concentrations 3

Duration:

14 d

Dose descriptor:

LC50

Effect conc.:

36.3 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other: 3-Methylaniline

Effect concentrations 4

Duration:

14 d

Dose descriptor:

LC50

Effect conc.:

10.7 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other: 4-Methylaniline

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Remarks:

No mortality in the controls.

Conclusions:

Aniline appeared to be slightly toxic to fish (LC50> 100 mg/L), while the methylated anilines were more toxic with LC50 values between 10 and 100 mg/L.