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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

No toxicokinetic studies have been conducted with isoamylene in animals or humans.  Being an olefin, isoamylene would be expected to form an epoxide intermediate.  Mice are likely to form the epoxide intermediate (P450 enzyme mediated) at a higher rate than rats and this would be hydrolyzed by the enzyme epoxide hydrolase at a lower rate in mice than in rats.  These metabolic differences between mice and rats would result in higher epoxide levels in mice compared with rats at equivalent isoamylene exposure concentrations. This might explain the higher levels of micronucleated erythrocytes in the bone marrow of mice compared with rats when exposed to 10,000 ppm 2-methylbut-2-ene (see CSR section