Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Studies in Animals

The skin sensitization potential of 2 -methyl-2 -butene (2M2B), the main component of isoamylene, was assessed using the guinea-pig maximization method of Magnusson and Kligman (1969). None of the animals showed any positive reactions 24 or 48 hours after the removal of the challenge patch, it can be concluded that 2M2B is not a skin sensitizer in guinea pigs (SRC, 1980).

Human data

No data available


Migrated from Short description of key information:
Isoamylene is not a skin sensitiser.

Respiratory sensitisation

Endpoint conclusion
Additional information:

Respiratory Tract

No specific respiratory sensitisation tests have been conducted in animals. There is no evidence of respiratory sensitisation from existing animal study data.

Studies in Humans

No data available


Migrated from Short description of key information:
There are no specific studies available, but also no evidence of respiratory sensitisation from existing data.

Justification for classification or non-classification

No classification for sensitisation is warranted under DSD or CLP.