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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Pre-GLP, pre-guideline study, which is to a great extent according to principles similar to those described in OECD TG 401

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1964

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Allyl hexanoate
EC Number:
204-642-4
EC Name:
Allyl hexanoate
Cas Number:
123-68-2
Molecular formula:
C9H16O2
IUPAC Name:
allyl hexanoate
Details on test material:
Name: Allyl caproate (allyl hexanoate)
No further details provided

Test animals

Species:
rat
Strain:
Osborne-Mendel
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Young, adult rats
- 180 to 350 g
- Animals were fasted 18 hours prior to oral exposure

ENVIRONMENTAL CONDITIONS
- No details on environmental conditions provided

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
No details reported
Doses:
Not reported
No. of animals per sex per dose:
Five males, five females per dose group
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not reported
- Necropsy of survivors performed: not reported
Statistics:
LD50 values were computed by the method of Litchfield and Wilcoxon (1949)

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
218 mg/kg bw
Based on:
test mat.
95% CL:
186 - 255
Mortality:
Animals were found dead between 4 and 18 hours after single oral exposure
Clinical signs:
other: Depression, scrawny appearance
Gross pathology:
No data

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category III
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The substance was acutely toxic to rats after a single oral exposure. Due to the observed LD50 of 218 mg/kg bw the substance is to be classified into Acute Toxicity Hazard Category 3 according to the CLP regulation (second amendment of March 2011).
Executive summary:

The acute oral toxicity of the test substance allyl caproate (allyl hexanoate) was studied in a pre-GLP, pre-guideline study which to a great extent followed the standard acute method described in OECD TG 401. Groups of 10 rats of the Osborne-Mendel strain evenly distributed between the sexes received single oral doses of the test substance by oral gavage. The animals were then observed for signs of toxicity during a period of 14 days. Non-mortal clinical effects including depression and scrawny appearance were observed. In this study, mortality of exposed animals was observed between 4 and 18 hours after a single oral exposure. The LD50 value calculated by the method of Litchfield and Wilcoxon (1949) was 218 mg/kg bw with a 95% confidence level ranging from 186 to 255 mg/kg bw. This LD50 value triggers classification according to CLP (second amendment of March 2011) into Acute Toxicity Hazard Category 3.