Allyl hexanoate

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Non-GLP, slightly deviating from guideline

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1974

Report date:

1974

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Deviations:

yes

Principles of method if other than guideline:

Groups of three animals, except the high dose group of two animals, were exposed topically to one dermal dose of test substance. Animals were observed during a period of 14 days.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Allyl hexanoate

EC Number:

204-642-4

EC Name:

Allyl hexanoate

Cas Number:

123-68-2

Molecular formula:

C9H16O2

IUPAC Name:

allyl hexanoate

Details on test material:

- Name of test material (as cited in study report): Allyl hexanoate
- Analytical purity: not reported
- Impurities (identity and concentrations): not reported

Test animals

Species:

rabbit

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

Not reported

Administration / exposure

Type of coverage:

not specified

Vehicle:

not specified

Duration of exposure:

Not reported

Doses:

0.313, 0.625, 1.25 and 5.0 g/kg bw

No. of animals per sex per dose:

3, except high dose: 2

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: not reported

Statistics:

Not reported

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

820 mg/kg bw

Based on:

test mat.

95% CL:

700 - 940

Mortality:

In the low dose groups 313 and 625 mg/kg bw, no animal died during the observation period of 14 days. In the dose group of 1250 mg/kg bw, one animal died on day one and two animals died on day two following dermal exposure. In the high dose group of 5000 mg/kg bw, all animals died on day one following dermal exposure.

Clinical signs:

other: Diarrhea was obserwed in one animal at 625 and 1250 mg/kg bw dose groups, whereas at 5000 mg/kg bw dose group symptom was obserwed in two animals.

Gross pathology:

Not reported

Other findings:

In the dose group of 313 mg/kg bw, a moderate redness was obserwed in one animal, whereas moderate edema was obserwed in all three animals. In the dose group of 625 mg/kg bw, the both moderate redness and moderate edema were obserwed in all three animals. In the dose group of 1250 mg/kg bw, the both slight rednes and moderate redness were obserwed in one out of trhee animals, whereas slight edema was obserwed in two out of three animals.

Applicant's summary and conclusion

Interpretation of results:

Toxicity Category III

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The substance was acutely toxic to rabbits in an acute dermal toxicity test with an LD50 value of 820 mg/kg bw. The substance is classified into Acute Toxicity Category III according to CLP.

Executive summary:

The acute dermal toxicity of the test substance allyl hexanoate was studied in a non-GLP test according to principles slightly deviating from those of current guidelines. Groups of three animals were exposed to single dermal doses of 0.313, 0.625 and 1.25 g/kg bw, whereas a group of 2 animals was exposed to single dermal dose of 5.0 g/kg bw. Animals were observed during a period of 14 days. No mortality was observed in 0.313 and 0.625 g/kg bw dose groups. In 1.25 and 5.0 g/kg bw dose groups, respectively three out of three and two out of two animals were died within the first days of the observation period. The LD50 value was 0.82 g/kg bw with a 95 % confidence interval of 0.70 to 0.94 g/kg bw. Diarrhea was observed in one animal dosed with 0.625 and 1.25 g/kg bw and in two out of two animals dosed with 5.0 g/kg bw. Slight to moderate skin irritation was observed in animals of 0.313 to 1.25 g/kg bw dose groups.