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EC number: 202-696-3 | CAS number: 98-73-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: data contained in EU risk assessment report of the substance - credibility is assumed. Reference to origin (Shell Research Ltd. London)
Data source
Referenceopen allclose all
- Reference Type:
- other: EU risk assessment report
- Title:
- No information
- Author:
- Federal Institute for Occupational Safety and Health, Division for Chemicals and Biocides Regulation, Germany
- Year:
- 2 009
- Bibliographic source:
- European Union Risk Assessment Report, 4-tert-butylbenzoic acid, CAS No: 98-73-7, EINECS No: 202-696-3, p. 48, Final Approved Version, July 2009
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
Materials and methods
- Principles of method if other than guideline:
- Dermal acute toxicity (LD50) of the test substance determined using rats and rabbits, application percutaneous in DMSO solution or as dry powder
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-tert-butylbenzoic acid
- EC Number:
- 202-696-3
- EC Name:
- 4-tert-butylbenzoic acid
- Cas Number:
- 98-73-7
- Molecular formula:
- C11H14O2
- IUPAC Name:
- 4-tert-butylbenzoic acid
- Test material form:
- other: 30 % (w/v) solution in DMSO
Constituent 1
Results and discussion
Any other information on results incl. tables
The acute single dose percutaneous LD50 value of PTBBA (no data on purity) as a 30% solution in DMSO (w/v) was found to be approximately 300 mg/kg in Carworth Farm E strain (CFE) rats in a study using 2 males and 2 females each at dose levels of 75, 150, 300, and 900 mg/kg bw. After application of 75 mg/kg none of the rats died, after application of 150 mg/kg 0/2 males and 1/2 females died on day 2, after application of 300 mg/kg 2/2 males and 0/2 females died within 4 days, after application of 900 mg/kg all rats died within 4 days. No further information is given (Shell Research Ltd. London, unpublished report 1975).
In studies with New Zealand White rabbits, however, a dermal LD50 value of > 900 mg/kg bw for a 30% solution in DMSO (w/v), and of > 2000 mg/kg bw for the dry powder were determined. The acute single dose percutaneous LD50 value of 4-tert- butylbenzoic acid (no data on purity) as a 30% w/v solution in DMSO was found to be greater than 900 mg/kg, the maximum volume of the most concentrated solution that could be used. The LD50 value of the dry powder was found to be greater than 2000 mg/kg in rabbits. No pathological lesions were found in the tissues of the rabbits exposed to the powdered substance. No further information is given (Shell Research Ltd. London, unpublished report 1975).
Applicant's summary and conclusion
- Conclusions:
- According to the cited results the LD50 (percutaneous) of the test substance has been determined to be approximately 300 mg/kg in male and female Carworth Farm E strain (CFE) rats.
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