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EC number: 202-696-3 | CAS number: 98-73-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: data contained in EU risk assessment report of the substance - credibility is assumed. Reference to origin (Shell Development Company)
Data source
Referenceopen allclose all
- Reference Type:
- other: EU risk assessment report
- Title:
- No information
- Author:
- Federal Institute for Occupational Safety and Health, Division for Chemicals and Biocides Regulation, Germany
- Year:
- 2 009
- Bibliographic source:
- European Union Risk Assessment Report, 4-tert-butylbenzoic acid, CAS No: 98-73-7, EINECS No: 202-696-3, p. 50, Final Approved Version, July 2009
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 950
Materials and methods
- Principles of method if other than guideline:
- Determination of oral LD 50 of the test substance by intragastical administration of different concentrations in an aqueous suspension of gum acacia.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-tert-butylbenzoic acid
- EC Number:
- 202-696-3
- EC Name:
- 4-tert-butylbenzoic acid
- Cas Number:
- 98-73-7
- Molecular formula:
- C11H14O2
- IUPAC Name:
- 4-tert-butylbenzoic acid
- Details on test material:
- - Name of test material (as cited in study report) and analytical purity:
4-tert-butylbenzoic acid, containing 5 % of the m-compound (3-tert-butylbenzoic acid, Shell production grade)
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Swiss inbred
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- white mice
Administration / exposure
- Route of administration:
- other: intragastic
- Vehicle:
- other: gum acacia in water
- Details on oral exposure:
- administration of an aqueous suspension of the test substance in gum acacia
- Doses:
- 350, 400, 550, 600, 650, 700, and 800 mg/kg bw
- No. of animals per sex per dose:
- 10
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 568 mg/kg bw
Any other information on results incl. tables
Doses of 350, 400, 550, 600, 650, 700, and 800 mg/kg bw were given to 10 mice each resulting in the following mortalities: after administration of 350 mg/kg 1/10 mice died on day 2; after administration of 400 mg/kg 4/10, after 550, 600, and 650 mg/kg 5/10 each, after 700 mg/kg 7/10, and after 800 mg/kg all mice died within 24 hours. The mice were mildly depressed within 1/3 hours after dosing. Within an hour, signs of muscular distress, marked incoordination and the Straub tail effect (spinal cord excitant) were present. At 5 hours a paralysis of the forelegs was evident in two thirds of the mice. In 3 of these, response of the tail and paws to painful stimuli was depressed or absent, but recovery occasionally followed even this deep depression. The pathologic changes noted in the 22 mice autopsied included signs off lung irritation, hemorrhage of the lungs, increased pigmentation of the liver, denuding of the epithelium of the intestines, and hyperemia of the intestines.
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