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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Metbolism of the surfactants sodium undecyltriethoxy sulphate and sodium dodecyltriethoxy sulphate in the rat
Author:
Taylor, A.J., et al.
Year:
1978
Bibliographic source:
Biochem. J. 174, 405-412

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Sodium 2-[2-[2-(dodecyloxy)ethoxy]ethoxy]ethyl sulphate
EC Number:
236-091-0
EC Name:
Sodium 2-[2-[2-(dodecyloxy)ethoxy]ethoxy]ethyl sulphate
Cas Number:
13150-00-0
IUPAC Name:
sodium 2-{2-[2-(dodecyloxy)ethoxy]ethoxy}ethyl sulfate
Details on test material:
- Name of test material : sodium 2-[2-[2-(dodecyloxy)ethoxy]ethoxy]ethyl sulphate
- Substance type : Organic
- Physical state : Liquid
Radiolabelling:
yes

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: Oral, intraperitoneal or intravenous
Vehicle:
not specified
Details on exposure:
Authors studied the metabolic fate of orally, intraperitoneally or intravenously administered 14C-CllAE3S and 14C-C12AE3S in the rat.
Duration and frequency of treatment / exposure:
Details not available
Doses / concentrations
Remarks:
Doses / Concentrations:
Details not available
No. of animals per sex per dose / concentration:
Details not available

Results and discussion

Main ADME resultsopen allclose all
Type:
absorption
Results:
After oral exposure, the chemical is readily absorbed in the gastrointestinal tract in man and rat. The dermal absorption of the chemical is relatively poor as can be expected from an ionic molecule.
Type:
distribution
Results:
Since metabolism of the chemical has been reported, it is likely to be distributed in the liver where much of the metabolism takes place.
Type:
metabolism
Results:
Both compounds were extensively metabolized (omega and beta oxidation) with the proportion of radioactivity appearing in urine and respired air generally independent of the route of administration.
Type:
excretion
Results:
By the oral route, 67% of the administered radioactivity with CllAE3S appeared in the urine of male rats compared to 45% in females; expired air contained 19% and 35% of administered radioactivity respectively; 4-5% was present in faeces for both sexes.

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
2-(triethoxy sulphate) acetic acid (source chemical - C12AE3S)
3-(triethoxysulfate) propionic acid (source chemical - CllAE3S)

Bioaccessibility (or Bioavailability)

Bioaccessibility (or Bioavailability) testing results:
The length of the ethoxy1ate portion in an AES molecule seems to have an important impact on the biokinetics of AES in humans and in the rat.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): low bioaccumulation potential based on study results
Since the chemicals 14C-CllAE3S and 14C-C12AE3S (AES – Alcohol Ethoxy Sulphates) were readily absorbed in the gastrointestinal tract in man and rat, metabolized and excreted out of the living system through the urine and feaces (longer ethoxylate chains (>7-9 EO units), it can be concluded that they shall exhibit low bio-accumulation potential.
Executive summary:

Since the chemicals14C-CllAE3S and 14C-C12AE3S (AES – Alcohol Ethoxy Sulphates) were readily absorbedin thegastrointestinal tract in man and rat, metabolized and excreted out of the living system through the urine and feaces (longer ethoxylate chains (>7-9 EO units), it can be concluded that they shall exhibit low bio-accumulation potential.