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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Inter-species variation in dermal reactivity
Author:
R. E. DAVIES, K. H. HARPER and S. R. KYNOCH
Year:
1972
Bibliographic source:
J. Soc. Cosmet Chem 23 371-381(1972)

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
In vivo potential dermal irritancy of Sodium Lauryl Sulphate was assessed in rabbit after application for 24 hrs.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium dodecyl sulphate
EC Number:
205-788-1
EC Name:
Sodium dodecyl sulphate
Cas Number:
151-21-3
Molecular formula:
C12H25NaO4S
IUPAC Name:
sodium dodecyl sulfate
Details on test material:
- Name of test material : Sodium Lauryl Sulphate
- Molecular formula : NaC12H25SO4
- Molecular weight : 288.372
- Substance type : Organic
- Physical state : Solid

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
occlusive
Preparation of test site:
abraded
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
1% and 5% concentration
Duration of treatment / exposure:
24 hrs
Observation period:
24 h and 72 h
Number of animals:
Groups of six rabbits

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Time point:
other: 24 h and 72 h
Score:
0.2
Reversibility:
no data
Remarks on result:
other: at 1% concentration
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Time point:
other: 24 h and 72 h
Score:
2
Reversibility:
no data
Remarks on result:
other: at 5% concentration

Applicant's summary and conclusion

Interpretation of results:
Category 3 (mild irritant)
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The Primary Irritation Index (PII) score of Sodium Lauryl sulphate in New Zealand White Rabbit at 1% and 5% concentration was found to be 0.2 and 2 respectively.
Executive summary:

Potential dermal irritancy of Sodium Lauryl Sulphate was assessed inNew Zealand Whiterabbit at1% and 5% concentrationfor 24 hrs.The Primary Irritation Index (PII) score was found to be 0.2 at 1 % and 2 at 5% concentration. From this score it is concluded that the substanceSodium Lauryl Sulphate is mildly irritating to rabbit.

 

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