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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Toxicological Studies on Sodium Lauryl Glyceryl Ether Sulfonate and Sodium Lauryl Trioxyethylene Sulfate
Author:
T. W. TUSING, 0. E. PAYNTER, D. L. OPDYKE, AND FRED H. SNYDER
Year:
1962
Bibliographic source:
TOXICOLOGY AND APPLIED PHARMACOLOGY 4, 402-409 (1962)

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Acute toxicity of Sodium Lauryl Trioxyethylene Sulfate was assessed in Sprague-Dawley rats
GLP compliance:
not specified
Test type:
fixed dose procedure
Limit test:
no

Test material

Constituent 1
Reference substance name:
Sodium 2-[2-[2-(dodecyloxy)ethoxy]ethoxy]ethyl sulphate
EC Number:
236-091-0
EC Name:
Sodium 2-[2-[2-(dodecyloxy)ethoxy]ethoxy]ethyl sulphate
Cas Number:
13150-00-0
IUPAC Name:
sodium 2-{2-[2-(dodecyloxy)ethoxy]ethoxy}ethyl sulfate
Details on test material:
- Name of test material : sodium 2-[2-[2-(dodecyloxy)ethoxy]ethoxy]ethyl sulphate
- Molecular formula : C18H37NaO7S
- Molecular weight : 420.53695
- Substance type : Organic
- Physical state : Liquid

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
Weight at study initiation : 200- to 250-g

Administration / exposure

Route of administration:
other: Stomach tube
Vehicle:
water
Details on oral exposure:
Graded doses of Sodium Lauryl Trioxyethylene Sulfate, in aqueous solution, were administered by stomach tube to Sprague- Dawley rats in the post absorptive condition
- Concentration in vehicle: 1.82 (1.51-2.19) g/kg or 1820 (1510-2190) mg/Kg
Doses:
1.82 (1.51-2.19) g/kg i.e [1820 (1510-2190) mg/Kg
No. of animals per sex per dose:
The rats were approximately equally divided between the sexes.
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: The animals were observed for 2 weeks following treatment

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 820 other: mg/kg
Based on:
test mat.
Mortality:
No data
Clinical signs:
other: No data
Gross pathology:
No data

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute oral LD50 value of Sodium Lauryl Trioxyethylene Sulfate in Sprague- Dawley rats was observed at dose concentration of 1.82 (1.51-2.19) g/kg i.e [1820 (1510-2190) mg/Kg]
Executive summary:

The acute toxicity of sodium lauryl trioxyethylene sulfate has been studied in rats.Aqueous solution ofsodium lauryl trioxyethylene sulfate was administered toSprague- Dawley rats by stomach tube in the post absorptive condition. All the rats were observed for 2 weeks following treatment. LD50 values determined was 1.82 g/kg (1820 mg/kg)

 

 

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