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Registration Dossier
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EC number: 221-416-0 | CAS number: 3088-31-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicological Studies on Sodium Lauryl Glyceryl Ether Sulfonate and Sodium Lauryl Trioxyethylene Sulfate
- Author:
- T. W. TUSING, 0. E. PAYNTER, D. L. OPDYKE, AND FRED H. SNYDER
- Year:
- 1 962
- Bibliographic source:
- TOXICOLOGY AND APPLIED PHARMACOLOGY 4, 402-409 (1962)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Acute toxicity of Sodium Lauryl Trioxyethylene Sulfate was assessed in Sprague-Dawley rats
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- Sodium 2-[2-[2-(dodecyloxy)ethoxy]ethoxy]ethyl sulphate
- EC Number:
- 236-091-0
- EC Name:
- Sodium 2-[2-[2-(dodecyloxy)ethoxy]ethoxy]ethyl sulphate
- Cas Number:
- 13150-00-0
- IUPAC Name:
- sodium 2-{2-[2-(dodecyloxy)ethoxy]ethoxy}ethyl sulfate
- Details on test material:
- - Name of test material : sodium 2-[2-[2-(dodecyloxy)ethoxy]ethoxy]ethyl sulphate
- Molecular formula : C18H37NaO7S
- Molecular weight : 420.53695
- Substance type : Organic
- Physical state : Liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Weight at study initiation : 200- to 250-g
Administration / exposure
- Route of administration:
- other: Stomach tube
- Vehicle:
- water
- Details on oral exposure:
- Graded doses of Sodium Lauryl Trioxyethylene Sulfate, in aqueous solution, were administered by stomach tube to Sprague- Dawley rats in the post absorptive condition
- Concentration in vehicle: 1.82 (1.51-2.19) g/kg or 1820 (1510-2190) mg/Kg - Doses:
- 1.82 (1.51-2.19) g/kg i.e [1820 (1510-2190) mg/Kg
- No. of animals per sex per dose:
- The rats were approximately equally divided between the sexes.
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: The animals were observed for 2 weeks following treatment
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 820 other: mg/kg
- Based on:
- test mat.
- Mortality:
- No data
- Clinical signs:
- other: No data
- Gross pathology:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 value of Sodium Lauryl Trioxyethylene Sulfate in Sprague- Dawley rats was observed at dose concentration of 1.82 (1.51-2.19) g/kg i.e [1820 (1510-2190) mg/Kg]
- Executive summary:
The acute toxicity of sodium lauryl trioxyethylene sulfate has been studied in rats.Aqueous solution ofsodium lauryl trioxyethylene sulfate was administered toSprague- Dawley rats by stomach tube in the post absorptive condition. All the rats were observed for 2 weeks following treatment. LD50 values determined was 1.82 g/kg (1820 mg/kg)
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