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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Toxicological Studies on Sodium Lauryl Glyceryl Ether Sulfonate and Sodium Lauryl Trioxyethylene Sulfate
Author:
T. W. TUSING, 0. E. PAYNTER, D. L. OPDYKE, AND FRED H. SNYDER
Year:
1962
Bibliographic source:
TOXICOLOGY AND APPLIED PHARMACOLOGY 4, 402-409 (1962)

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Acute toxicity of Sodium Lauryl Trioxyethylene Sulfate was assessed in Sprague-Dawley rats
GLP compliance:
not specified
Test type:
fixed dose procedure
Limit test:
no

Test material

Constituent 1
Reference substance name:
Sodium 2-[2-[2-(dodecyloxy)ethoxy]ethoxy]ethyl sulphate
EC Number:
236-091-0
EC Name:
Sodium 2-[2-[2-(dodecyloxy)ethoxy]ethoxy]ethyl sulphate
Cas Number:
13150-00-0
IUPAC Name:
sodium 2-{2-[2-(dodecyloxy)ethoxy]ethoxy}ethyl sulfate
Details on test material:
- Name of test material : sodium 2-[2-[2-(dodecyloxy)ethoxy]ethoxy]ethyl sulphate
- Molecular formula : C18H37NaO7S
- Molecular weight : 420.53695
- Substance type : Organic
- Physical state : Liquid

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
Weight at study initiation : 200- to 250-g

Administration / exposure

Route of administration:
other: Stomach tube
Vehicle:
water
Details on oral exposure:
Graded doses of Sodium Lauryl Trioxyethylene Sulfate, in aqueous solution, were administered by stomach tube to Sprague- Dawley rats in the post absorptive condition
- Concentration in vehicle: 1.82 (1.51-2.19) g/kg or 1820 (1510-2190) mg/Kg
Doses:
1.82 (1.51-2.19) g/kg i.e [1820 (1510-2190) mg/Kg
No. of animals per sex per dose:
The rats were approximately equally divided between the sexes.
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: The animals were observed for 2 weeks following treatment

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 820 other: mg/kg
Based on:
test mat.
Mortality:
No data
Clinical signs:
other: No data
Gross pathology:
No data

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute oral LD50 value of Sodium Lauryl Trioxyethylene Sulfate in Sprague- Dawley rats was observed at dose concentration of 1.82 (1.51-2.19) g/kg i.e [1820 (1510-2190) mg/Kg]
Executive summary:

The acute toxicity of sodium lauryl trioxyethylene sulfate has been studied in rats.Aqueous solution ofsodium lauryl trioxyethylene sulfate was administered toSprague- Dawley rats by stomach tube in the post absorptive condition. All the rats were observed for 2 weeks following treatment. LD50 values determined was 1.82 g/kg (1820 mg/kg)