Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

The animals did not show any clinical signs during the course of this study and no deaths were observed. The stimulation indices determined at DHA concentrations of 12.5, 25, and 50 % clearly demonstrate that DHA is not sensitizing to the skin under the conditions of this test.

Migrated from Short description of key information:
The skin sensitizing potential of DHA was evaluated in a Local Lymph Node Assay in mice following the OECD Guideline 429. The analysis of the results shows that DHA is not a skin sensitizer.

Justification for classification or non-classification

Given the results of the LLNA, DHA is evaluated as non-sensitizing to the skin.