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Administrative data

Description of key information

The acute toxicity of DHA was studied in rats using oral, intraperitoneal and inhalative route of administration. Based on the results of these studies, no evidence for toxicity was observed independent of the route of application .

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
discriminating dose
16 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
discriminating conc.
5 mg/m³

Additional information

DHA showed no toxicity in acute toxicity tests in rats irrespective of the route of administration used. In an acute oral toxicity study where DHA was given to rats up to 16000 mg/kg, no mortality was observed. No deaths were observed in rats given DHA at dose levels of up to 6400 mg/ kg by the intraperitoneal route, and no toxicity was observed in an acute inhalation study in rats up to the limit concentration of ≥ 5 mg/L air.

Justification for classification or non-classification

DHA should not be classified with regard to acute toxicity as the LD50 values exceed 16000 mg/kg body weight and 5 mg/L air after oral and inhalative treatment, respectively.