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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The review publications give important information on the metabolism/kinetic of glycerol which is structurally closely related to DHA. The essential relevant information of this review articles are presented in the Executive Summary. No detailed Materials and Methods are displayed.

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
GLYCEROL UTILIZATION AND ITS REGULATION IN MAMMALS
Author:
Lin
Year:
1977
Bibliographic source:
Ann. Rev. Biochem. 1977. 46.765-95
Reference Type:
review article or handbook
Title:
Cerebral dehydration action of glycerol
Author:
Tourtelotte, Reinglass,Newkirk,
Year:
1970
Bibliographic source:
Clinical Pharmacology and Therapeutics 13(2): 159-171, 1970 (68)
Reference Type:
review article or handbook
Title:
Glycerol: Its Metabolism and Use as an Intravenous Energy Source
Author:
Tao,KELLEY,YOSHIMURA,BENJAMIN
Year:
1983
Bibliographic source:
J. Parent. Ent. Nutr. 7 (1983), 479-488 (67)

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Glycerol
EC Number:
200-289-5
EC Name:
Glycerol
Cas Number:
56-81-5
Molecular formula:
C3H8O3
IUPAC Name:
glycerol
Constituent 2
Reference substance name:
1,2,3-Propanetriol
EC Number:
616-940-5
IUPAC Name:
1,2,3-Propanetriol

Results and discussion

Preliminary studies:
please refer to Executive summary

Toxicokinetic / pharmacokinetic studies

Details on absorption:
please refer to Executive summary
Details on distribution in tissues:
please refer to Executive summary
Details on excretion:
please refer to Executive summary

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): no bioaccumulation potential based on study results
Executive summary:

These publications were used in the OECD evaluation of glycerol (SIDS). OECD concluded the following:

Data from studies in humans and animals indicate glycerol is rapidly absorbed in the intestine and the stomach, distributed over the extracellular space (Lin 1977, Tourtelotte 1970) and excreted. Glycerol is phosphorylated to alpha-glycerophosphate by glycerol kinase predominantly in the liver (80-90%) and kidneys (10-20%) and incorporated in the standard metabolic pathways to form glucose and glycogen (Tao 1983, Lin 1977).

Considering the close structural relationship of glycerol and DHA it can be concluded that DHA is absorbed and excreted in a similar manner than glycerol, i.e. DHA is also rapidly and completely absorbed.