Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
09/08-11/08
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2008
Report date:
2008

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
no
GLP compliance:
no
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-dihydroxyacetone
EC Number:
202-494-5
EC Name:
1,3-dihydroxyacetone
Cas Number:
96-26-4
Molecular formula:
C3H6O3
IUPAC Name:
1,3-dihydroxyacetone
Details on test material:
Purity: 100.2 %

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
-1.95
Temp.:
20 °C
Remarks on result:
not measured/tested
Remarks:
pH was not measured

Any other information on results incl. tables

According to the preliminary test the solubility of the test item in n-octanol is between 1.52 g/l and 5.33 g/l.The partition coefficient POW was estimated from the saturation concentrations in n-octanol and water. The saturation concentration of the test item in water was given by the main test of project 20080630.01 (please refer to 4.8): at 20°C the water solubility cS was determined to (without correction of the purity): cSwater = 930 g/l. The n-octanol solubility cSoctanol of the test item at a temperature of 20°C was determined to (without correction of the purity): cSoctanol = 10.5 g/l

From the individual solubilities the log POW can be calculated:

POW= 10.5 g/l / 930 g/l

POW= 0.01129

log POW  =  - 1.95

A standard solution was analysed one day after preparation and showed a recovery value of 97.9 %. This observation indicates a good stability of the test item over this time period.

Applicant's summary and conclusion

Conclusions:
The partition coefficient n-octanol/water of the test item at 20 °C, performed according to the flask method (individual solubilities in water and n-octanol), was determined to: log POW = - 1.95
Executive summary:

The partition coefficient of DHA in n-octanol and water was determined according to OECD 107. Considering the maximum solubilities in n-octanol and water the log POW is -1.95.