Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-802-8 | CAS number: 99-93-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
There are no guideline studies available which asses the test substance's chronic toxicity to fish. Thus, based on the structural and physico-chemical similarity as well as the results of the OECD Toolbox, the assessment of long-term toxicity on fish can be covered by the data available for phenol, chlorophenol, p-cresol and tert-butylphenol.
According to the OECD Toolbox, 4-hydroxyacetophenone falls in the non-specific (polar narcotic) categories of “Phenols” (US EPA New Chemical Category and ECOSAR) and “Phenols and Anilines” (OASIS MOA). Substances classified as polar narcotic are thought to act by a mechanism similar to the inert narcotic compounds, i. e. by perturbation of the cell membrane, but exhibit above baseline toxicity due to their hydrogen bond donor activity. The aquatic toxicity of polar narcotics typically depends on their lipophilicity and increases with the logKow. In the data summarised below, p-tert-butylphenol with the highest logKow, also exhibits the high toxicity.
Based on the data available for other para-substituted phenols (see below), 4-hydroxyacetophenone is expected to have long-term effects on both fish and daphnia. However, due to the significantly lower logKow, the toxicity is expected to be less than for p-tert-butylphenol. In order to confirm these expectations, a long-term study with Daphnia magna has been conducted which resulted in a NOEC of >= 1 mg/L (meas. conc.). An additional long-term fish test would, however, most probably not reveal any further information, relevant for the risk assessment. Therefore, and for the purpose of animal welfare, a chronic fish test has not been proposed.
Substance |
CAS-No. |
Molecular weight (g/mol) |
logKow |
Water solubility (mg/L) |
NOEC Fish (mg/L) |
NOEC Daphnia (mg/L) |
4-hydroxyacetophenone |
99-93-4 |
136.1 |
1.35(a |
10000 |
n.a. |
n.a. |
Phenol |
108-95-2 |
94.1 |
1.45(b |
70000 |
0.1(b |
0.46(b |
p-Cresol |
106-44-5 |
108.1 |
1.94(c |
21500 |
1.35(d |
1.0(e |
p-tert-Butylphenol |
98-54-4 |
150.2 |
3.29(f |
610000 |
0.1(g |
0.73(f |
p-Chlorophenol |
106-48-9 |
128.6 |
2.39(h |
n.a. |
n.a. |
0.19(i |
n.a.: not available
a) Hansch,C et al., 1995, secondary source SRC PhysProp Database
b) EU Risk Assessment Report Phenol, 2006
c) Hansch,C et al., 1995, secondary source ACS Professional Reference Book. American Chemical Society,,
d) Barron MG and Adelman IR, 1984, Canad. J. Fish. Aquat. Sci. 41(1), 141-150
e) Kuehn et al., 1989, Water Res. 23(4), 501-510
f) OECD SIDS, 2000
g) ECHA published IUCLID
h) Hansch,C et al., 1995, secondary source KOWWIN v.1.67 Database
i) The Official Bulletin of the Ministry of International Trade and,
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.