Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Additional information:

4 -Hydroxyacetophenone was tested in a guinea pig maximization test (UBTL Inc., 1992) with an intradermal injection (as a 5% solution in propylene glycol with and without Freund's adjuvant) and then by a topical application (5% in propylene glycol) eight days later. Two weeks after the second induction, animals were challenged with 0.5 g of test material as a 75% preparation in petrolatum using a 24-h dermal exposure. No sensitizing properties were found.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

Based on the available data, classification is not warranted according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.