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Short-term toxicity to fish

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Description of key information

LC50 (96 h) = 0.046 a.i./L ( Oncorhynchus mykiss )

Key value for chemical safety assessment

Additional information

The determination of the acute toxicity of tetramethylthiuram disulfide (CAS No. 137-26-8) to fish species has been investigated in several studies. The key study (Peither, 2000) was conducted according to OECD Guideline No. 203 (1992): Fish Acute Toxicity test, under GLP conditions. After 96 hours of exposure to the test compound (static water regime), lethal effects in Oncorhynchus mykiss were observed in all but two of the tested concentrations, resulting in a LC50 value of 0.046 mg a.i./L. Two more tests conducted under comparable conditions with Pimephales promelas and Lepomis macrochirus resulted in LC50 values of 0.27 and 0.13 mg a.i./L respectively. An additional study testing tetramethylthiuram disulfide on a marine fish species (Cyprinodon variegatus) showed similar toxicity values, with a LC50 value of 0.54 mg a.i./L.