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Description of key information

Thiram is well and rapidly absorbed from the gastro intestinal tract. The majority of the dose is eliminated from the body within four days after dosing either via urine (~34%) or the expired air (~48%), and does not accumulate in the organism. 
The highest tissue levels of thiram are found in blood and liver, independent of the administered dose and the elapsed time.
Thiram is rapidly degraded by the rats to more polar products. The urine, which held ca. 30% of the [14C]-thiram-derived radioactivity, contained virtually no unchanged [14C]-thiram. Five urinary metabolites were detected and isolated by HPLC and identified by mass spectrometry.
The dermal absorption values for thiram when formulated as Thiram 80 WG were estimated to be 3% and 12%, respectively, for the commercial formulation and the 1.6 g/L in-use dilution.
Thus, 3% is the assumed dermal absorption for neat thiram.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential
Absorption rate - oral (%):
100
Absorption rate - dermal (%):
3

Additional information