Registration Dossier

Diss Factsheets

Administrative data

Description of key information

Thiram is harmful by the oral and inhalation route.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
1 850 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
LC50
Value:
4.42 mg/m³

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Additional information

Acute oral exposure to thiram led to massive body weight loss, apathy, reduced locomotive activity, laboured breathing, ungroomed appearance, reduced faecal excretion, (half) closed and moist eyes, and tremors of the head.

However, by dermal application thiram shows only very low toxicity. After whole body inhalation exposure to thiram, observed toxicological effects consisted of activity decrease, constricted pupils, gasping, lacrimation, nasal discharge, piloerection, polyuria, ptosis, and salivation.

Justification for classification or non-classification

On basis of the oral LD50 in females (1850 mg/kg bw), and the inhalation LC50, according to Directive 2001/59/EC, thiram has to be classified: Xn, R20/22: Harmful by inhalation and if swallowed.

CLP classification for acute lethal effects:

Acute Oral Cat.4, acute inhalation Cat. 4, H302, H312