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Long-term toxicity to fish

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Description of key information

NOEC (33 d) = 4.6 ug/L (Pimephales promelas)

Key value for chemical safety assessment

Additional information

The determination of the chronic toxicity of tetramethylthiuram disulfide (CAS No. 137-26-8) to fish species was investigated in two studies. The key study (Krueger and Kendall, 2008) was conducted according to OECD Guideline No. 210: Fish, Early Life Stage Toxicity test (1992) under GLP conditions. Fish embryos and, later on, larvae were exposed for 33 days (5 days hatch and 28 days post-hatch) to14C-thiram under a flow-through water regime. Hatching success of fish embryos in the treatment groups did not differ from that in the controls. However, significant effects were observed in larval survival and growth, resulting in a NOEC = 4.6 ug a.i./L. The results from the supporting study (Memmert, 2001), conducted with juvenile fishes in a static water regime, exhibited NOECs of 0.02 and 0.012 mg a.i./L for mortality and growth parameters respectively.